Diabetic Peripheral Neuropathy: Current Concepts and Future Perspectives

Neuropathic pain is defined by International Association for Study of Pain (IASP) as pain arising as a direct consequence of lesion or disease of the system either somatosensory system either at peripheral or central level [1]. Diabetic neuropathy and Postherpetic neuralgia are major causes of neuropathic pain. It has been seen that neuropathy is a common complication of diabetes, affecting up to 50% of patients [2-6]. A consensus statement produced by an international meeting on the diagnosis and management of diabetic neuropathy defined it as “the presence of symptoms and/or signs of peripheral nerve dysfunction in people with diabetes after the exclusion of other causes.”[7]. Although, there are many types of neuropathy with a variety of clinical presentations. This article focuses on one type of neuropathy, Peripheral Diabetic Neuropathy (PDN). In this review, we will focus on current aspect, future perspective, epidemiology, basic understanding and recent advances in mechanisms and management of diabetic neuropathy. Abstract